sunnuntai 28. elokuuta 2011

Vitamin B12

There are few studies where there has been good results using B12 vitamin in treatment of vitiligo. In studies there is also used Folic acid , but i want to address just b12 in this writing.
Most well know study perhaps is from l. Juhlin

Improvement of vitiligo after oral treatment with vitamin B12 and folic acid and the importance of sun exposure.


Department of Dermatology, University Hospital, Uppsala, Sweden.


The aim of this 2-year study was to test the hypothesis that folic acid, vitamin B12 and sun exposure could be helpful in treating vitiligo. One hundred patients with vitiligo were treated with oral folic acid and vitamin B12 after being informed that sun exposure might enhance repigmentation. They were requested to keep a record of sun exposure in summer and UVB irradiation in winter. The minimal treatment time suggested was 3-6 months but should be longer if improvement was achieved. Clear repigmentation occurred in 52 patients, including 37 who exposed their skin to summer sun and 6 who used UVB lamps in winter. Repigmentation was most evident on sun-exposed areas, where 38% of the patients had previously noted repigmentation during summer months. Total repigmentation was seen in 6 patients. The spread of vitiligo stopped in 64% of the patients after treatment. Folic acid and vitamin B12 supplementation combined with sun exposure can induce repigmentation better than either the vitamins or sun exposure alone. Treatment should continue as long as the white areas continue to repigment. Further studies are needed to determine ideal minimal dosages of vitamins and UV exposure, as well as treatment time.
In early of this summer i started using many supplements, B12 and Folic acid after of couple months i started to see results , but only in places where have been best exposure to sun. I have taked before B12 but there has been no results because there has to be combination of other supplements, Herbs and sun Exposure is very important.
Quality of Vitamin B12
Usually i take all vitamins in natural form, but is hard to take the massive amounts of natural Vitamin B12.

What is Vitamin B12?

Vitamin B12 is a term given to a class of water soluble chemicals that share structural similarity and physiologic activity in the body. These chemicals share a common complicated core of nitrogen and cobalt (called cobalamin) but differ in the attachment of other constituent molecules to the cobalt part. While many others exist in nature, there are four types that humans can utilize:
  • Cyanocobalamin (CN-Cbl)
  • Hydroxycobalamin (OH-Cbl)
  • Adenosylcobalamin (AdeCbl)
  • Methylcobalamin (MeCbl)
The Natural Source of Dietary B12
The natural origin of dietary B12 is ultimately bacteria. Many bacteria species produce this vitamin which is then ingested by animals. Humans then eat animal products to get their daily requirements. At one time it was thought that plants also created ample B12 but researchers have since shown this to not be the case. Plants may create B12-like molecules that look like the vitamin but lack and even hinder B12 activity in humans. This vitamin is created by bacteria in the human colon but it's not absorbed and thus is excreted in the feces. In some studies it was found that adequate vitamin B12 was obtained when fruits and vegetables were not washed and B12 producing bacteria were left on them.

Challenges with Synthetic Forms of B12

Cyanocobalamin (CN-Cbl) is cheap and easy to create and thus, the most commonly found form of B12 in supplements. Not found in nature, the challenge with CN-Cbl is that in order for it to have biological activity it must be processed in the liver in a pathway requiring several steps. These steps deal with the attached cyanide and require an important antioxidant called L-glutathione. L-glutathione (a tri-peptide made from the amino acids glutamic acid, cysteine, and glycine) is often already in short supply due to its use in other important missions. This process makes the liver work harder so those with impaired liver function may not efficiently convert CN-Cbl to a usable form. Also, while the cyanide released is minute, those with impaired or stressed liver function may possibly experience compounded effects like increased nausea. Therefore, this form of B12 is contraindicated in chronic hepatitis or in pregnant women already experiencing morning sickness. Hydroxycobalamin (OH-Cbl) is another inexpensive form that does not exhibit biological activity until liver manipulation.

More Absorbable Forms of B12

Adenosylcobalamin (AdeCbl) and methylcobalamin (MeCbl) are active forms that are less stable and more expensive but easier to absorb and readily used by the body. Documented research exists supporting their efficacy in conditions like liver disease, sleep disturbances, diabetic neuropathy, and anemia.
Many experts recommend to take B12 vitamin form of methylcobalamin and i think is it best when you consider take years. Best place to buy high quality vitamins at good price is IHERB if you are first time customer use my referal code UVU130 and you will save 5 dollars there is a link to supplement what i use

Pure Advantage, B-12, 500 mcg Spray, 1 fl oz

4 kommenttia:

  1. Tässä laadukas ja hyvin imeytyvä MTHF-foolihappo:

    Tässä laadukas ja hyvin kielen alta imeytyvä B12:

  2. Thanks for the comment. I am using missata Jarrow Formulas B vitamin complex. That formula use high guality b vitamins line methylcobalamin and new generation folic acid quatrefolic what you mentioned.i have planning write about quatrefolic soon in the blog. I rhino it is very important in vitiligo supplemation.

  3. This is the first time i am reading your post and admire that you posted article which gives users lot of information regarding particular topic thanks for this share. b12 methylcobalamin 5000 mcg